Dietary Transforming Growth Factor-Beta 2 (TGF-β2) Supplementation Reduces Methotrexate-Induced Intestinal Mucosal Injury in a Rat
Figure 7
Effects of MTX and TGF-β on enterocyte proliferation (A) and apoptosis (B).
Values are mean ± SEM. CONTR-control, MTX-methotrexate, TGF-β- transforming growth factor beta. *P<0.05 MTX and CONTR-TGF-β versus control, †P<0.05 MTX-TGF-β versus MTX rats. (C) Representative slides of cell proliferation and apoptosis following TGF-β2 administration during MTX-induced mucositis. MTX-treated animals showed a significant decrease in cell proliferation rates and concomitant increase in cell apoptosis compared to control animals. TGF-β2 administration in MTX rats resulted in a significant increase in cell proliferation and decrease in cell apoptosis compared to MTX animals.