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In-Depth Investigation of Archival and Prospectively Collected Samples Reveals No Evidence for XMRV Infection in Prostate Cancer

Figure 6

Lack of Diversity Among XMRV Strains Detected in Laboratory Cell Lines and Prostate Cancer Tissues.

By SNP analysis, single nucleotide differences between the sequences of 22Rv1-associated XMRV and XMRV genomes detected in prostate cancer tissues [VP35, VP42, and VP62(2006)] (red lollipops) are corrected by the deep sequencing coverage data (black lollipops). The depth of read coverage achieved at the nucleotide position corresponding to each SNP is displayed below the x-axis. All reads covering a given position yielded the same (corrected) nucleotide, indicating that previous nucleotide differences in published genomes [1] (red lollipops) are due to sequencing error. A natural A→G polymorphism in the XMRV genome [23], [38] is present at position 790 (cyan lollipop). Note that XMRV consensus genomes associated with 22Rv1, LNCaP, and the 3 XMRV-positive prostate cancer tissues are identical.

Figure 6