Altered Serotonin, Dopamine and Norepinepherine Levels in 15q Duplication and Angelman Syndrome Mouse Models
Figure 2
Serotonin (5HT) levels are elevated in Ube3a deficient mice in the striatum and cortex and decreased in paternal 7p duplication animals.
No significant change in 5HT was seen in Ube3a duplication animals in the striatum. Maternal 7p duplication animals did not show any significant changes in 5HT in either striatum or frontal cortex. In all cases, 5HT levels for each genotype were compared to wild type littermates from each cross (100%). Significant differences were found (p≤0.05 and n = 6) for all groups. *p≤0.05 compared to wild type littermate.