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Lipo-Endomorphin-1 Derivatives with Systemic Activity against Neuropathic Pain without Producing Constipation

Figure 9

Constipation-inducing activity of compound 3 relative to morphine following single i.v. bolus dose administration.

A) Lack of inhibitory effect of 3 in doses up to 16 µmol/kg on castor-oil induced diarrhea in rats in contrast to the significant inhibitory effects of morphine at 2 µmol kg/kg. B) Lack of effect of analog 3 (16 µmol/kg) and vehicle in contrast to the inhibitory effect of morphine (2 µmol/kg) on the gastrointestinal transit of a charcoal meal in rats. Data are the mean (± SEM). ***p<0.001, vs. vehicle (n = 8).

Figure 9

doi: https://doi.org/10.1371/journal.pone.0041909.g009