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Lipo-Endomorphin-1 Derivatives with Systemic Activity against Neuropathic Pain without Producing Constipation

Figure 8

Pre-treatment with the opioid receptor antagonist.

The anti-allodynic effects of single i.v. bolus doses of compound 3 were abolished by naloxone (10 mg/kg s.c.) in the ipsilateral hindpaws of opioid-naive CCI-rats (1.6 µmol/kg, n = 6) in a manner similar to morphine (2 µmol/kg) Each value is the mean (± SEM). **p<0.01, vs. vehicle pre-treated rats (n = 6).

Figure 8

doi: https://doi.org/10.1371/journal.pone.0041909.g008