Browse Subject Areas

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

< Back to Article

Lipo-Endomorphin-1 Derivatives with Systemic Activity against Neuropathic Pain without Producing Constipation

Figure 8

Pre-treatment with the opioid receptor antagonist.

The anti-allodynic effects of single i.v. bolus doses of compound 3 were abolished by naloxone (10 mg/kg s.c.) in the ipsilateral hindpaws of opioid-naive CCI-rats (1.6 µmol/kg, n = 6) in a manner similar to morphine (2 µmol/kg) Each value is the mean (± SEM). **p<0.01, vs. vehicle pre-treated rats (n = 6).

Figure 8