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Lipo-Endomorphin-1 Derivatives with Systemic Activity against Neuropathic Pain without Producing Constipation

Figure 7

Extent and duration of antinociception in the contralateral hindpaw of CCI-rats.

Single i.v. bolus doses of compounds 3 and 4 produced insignificant anti-allodynic responses in the contralateral hindpaws of CCI-rats in contrast to morphine at equi-effective doses. Each value is the mean (± SEM). ***p<0.001, vs. vehicle treated CCI-rats, p>0.05 for compounds 3 and 4 vs. vehicle (n = 6–8).

Figure 7

doi: https://doi.org/10.1371/journal.pone.0041909.g007