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Lipo-Endomorphin-1 Derivatives with Systemic Activity against Neuropathic Pain without Producing Constipation

Figure 6

Insignificant antinociception produced by compounds 1 and 2.

The highest doses of compounds 1 and 2 did not produce pain relief at 16 µmol/kg after single bolus i.v. administration to CCI-rats. Each value represents mean (± SEM) (n = 6–8).

Figure 6

doi: https://doi.org/10.1371/journal.pone.0041909.g006