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Lipo-Endomorphin-1 Derivatives with Systemic Activity against Neuropathic Pain without Producing Constipation

Figure 5

Antinociceptive dose-response curves for compounds 3 and 4.

Analogs 3 and 4 produced dose-dependent analgesia after single i.v. bolus administration to CCI-rats. The data are mean (± SEM).

Figure 5

doi: https://doi.org/10.1371/journal.pone.0041909.g005