TH17, TH22 and TReg Cells Are Enriched in the Healthy Human Cecum
Figure 10
Identification of RETN, TFF1 and FCRL5 as genes with expression levels that correlate with frequencies of TH17 and TReg cells.
(A) The frequency of TH17 cells was used as a quantitative variable to identify gene probes with correlated expression values using significance analysis of microarrays (SAM). Gene probes in red are positively correlated and gene probes in green are negatively correlated with TH17 cell frequency at a FDR of 0%. (B) Identification of gene probes correlated with frequency of CD4+CD25+FoxP3+ TReg cells. C) Real time PCR analysis of 40 biopsy samples confirms the positive correlation between TH17 cells with RETN expression, the negative correlation between TH17 cells with TFF1 expression, and the positive correlation between TReg cells with FCRL5 expression.