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Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Figure 6

Chronic, but not acute, ursolic acid treatment increases food intake and energy expenditure.

Mice were fed high fat diet (HFD) lacking or containing 0.27% ursolic acid (UA) for either 3 days (acute treatment) or 6 weeks (chronic treatment), and then food intake (A) and energy expenditure (B) were determined using a comprehensive lab animal monitoring system (CLAMS). Left panels: hourly measurements. Data are means from 12 mice per diet. Right panels: cumulative measurements during the dark and light periods. Data are means ± SEM from 12 mice per diet. P-values were determined with unpaired t-tests. *P<0.05.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0039332.g006