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Calcium Channel Blockers, More than Diuretics, Enhance Vascular Protective Effects of Angiotensin Receptor Blockers in Salt-Loaded Hypertensive Rats

Figure 5

Effect on coronary arterial thickening (A) and vascular phospho-ERK (B) of salt-loaded SHRSP.

Abbreviations used are the same as in Fig. 1. The upper panels in (A) indicate representative photomicrographs of the coronary artery in Sirius red-stained cardiac sections from each group. Each value represents the mean ± SEM (n = 12 in Ve, n = 7 in Ol, n = 7 in Az, n = 7 in Hy, n = 11 in Ol+Az, n = 11 in Ol+Hy, n = 12 in WKY). The upper panels in (B) indicate representative western blots in each group. Each value represents the mean ± SEM (n = 4 in each group). The value of phospho p44/42 ERK corrected for total p44/42 ERK provided the same results as the value of phospho p44/42 ERK corrected for tubulin.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0039162.g005