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Calcium Channel Blockers, More than Diuretics, Enhance Vascular Protective Effects of Angiotensin Receptor Blockers in Salt-Loaded Hypertensive Rats

Figure 3

Effect on vascular NADPH oxidase activity (A) and superoxide (B) of salt-loaded SHRSP.

Abbreviations used are the same as in Fig. 1. The upper panels in (B) indicate representative photomicrographs of carotid arterial DHE staining. Bar = 200 µm. Each value represents the mean ± SEM ((A) n = 8 in Ve, n = 7 in Ol, n = 7 in Az, n = 4 in Hy, n = 7 in Ol+Az, n = 7 in Ol+Hy, n = 8 in WKY; (B) n = 12 in Ve, n = 7 in Ol, n = 7 in Az, n = 7 in Hy, n = 11 in Ol+Az, n = 11 in Ol+Hy, n = 12 in WKY).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0039162.g003