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Simulated Evolution of Protein-Protein Interaction Networks with Realistic Topology

Figure 2

Degree centrality.

Degree () distributions in human (green), yeast (blue), and fly (red). Heavy lines are the median values from 50 simulations, and light lines are results of individual simulations. Points represent high-confidence empirical data for each organism (see Methods). Unless otherwise noted, color coding in the same in all plots. Quantitative comparisons between simulation and experiment (for DUNE and several other models) are detailed in SI.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0039052.g002