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Different Emotional Disturbances in Two Experimental Models of Temporal Lobe Epilepsy in Rats

Figure 2

Social interaction test.

(A) The juvenile exploration ratio represents time spent exploring the juvenile rat over the total time spent exploring the juvenile rat and the object, evaluated during the 10 min session of the test. Both SE models regardless of the strain, but especially LIP-treated animals, showed decreased preference for exploration of the juvenile conspecific. (B) Total distance traveled in the social interaction test. The results are presented as the mean ± SEM. * P<0.05; *** P<.0001; +++ P<.0001. Abbreviations: W: Wistar; SD: Sprague-Dawley; LIP: lithium-pilocarpine; KA: kainic acid.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0038959.g002