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Quantitative Assessment of Whole-Body Tumor Burden in Adult Patients with Neurofibromatosis

Figure 4

Results of unsupervised hierarchical clustering of patients based on relative tumor volume across body regions.

(This figure is an interactive display. It is currently available for at www.wholebodymri.org). Unsupervised hierarchical clustering of relative tumor volume across body region (head/neck, trunk, extremities) for 145 subjects with internal nerve sheath tumors. Total tumor volumes were combined and scaled for each patient. Regions with higher tumor burden are shown in yellow. Individual patients are represented as columns and the maximum intensity projection (MIP) of the whole-body MRI scan is shown to the right of the clustering figure. For each patient, the Gini coefficient is shown in the lower left and the whole-body tumor volume in the lower middle.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0035711.g004