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MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS

Figure 1

The power of MultiPhen in different scenarios of effect and correlation between phenotypes.

Power results based on simulations described in the text for MultiPhen (red lines) and the standard single-phenotype approach (black lines). Left panel: causal variant explains 0.5% of phenotypic variance of both phenotypes. Middle panel: causal variant explains 0.5% on the phenotypic variance of the first phenotype and 0.1% of the variance in the second phenotype. Right panel: causal variant explains 0.5% of phenotypic variance of the first phenotype and 0% of the second phenotype.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0034861.g001