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Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

Figure 4

Gut microbiota composition in control and high saturated fat diet (HFD) fed mice.

A: Relative abundance of main genera in fecal samples from control (open bars) and HFD (closed bars) mice (n = 16 per group). Data are shown as mean ± SEM. ***P<0.001, ** P<0.01 and *P<0.05 compared to control. Correlations between the abundance of Lactobacillus (B) and Oscillibacter (C) and weight changes. Gut microbiota profile was determined by metagenomic pyrosequencing from bacterial lineages in fecal samples.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0034233.g004