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Optogenetic Mimicry of the Transient Activation of Dopamine Neurons by Natural Reward Is Sufficient for Operant Reinforcement

Figure 5

Behavioral responses correlate with the number of ChR2 positive neurons.

Each point represents a single mouse. For each behavior, we measured the correlation for all ChR2 mice (long lines, p<0.01 for each behavior), as well as only the ChR2-H or ChR2-L mice (short lines). A, The y-axis indicates the difference in the number of operant responses at the active versus inactive ports (averaged across days 6–9; see Fig. 2A). B, Head speed. C, Rotations. In B and C, the y-axis indicates differences between stimulation and non-stimulation periods (see Fig. 4B,C).

Figure 5

doi: https://doi.org/10.1371/journal.pone.0033612.g005