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Optogenetic Mimicry of the Transient Activation of Dopamine Neurons by Natural Reward Is Sufficient for Operant Reinforcement

Figure 3

Rasters of response times during the operant task (90 minute sessions over 18 days in each of the 6 mice that displayed high levels of operant responding).

This is the same data summarized in Fig. 2A,B. Responses that were followed by optical stimulation are in black, and those not followed by optical stimulation are in red. Blue horizontal lines divide the acquisition and extinction periods. The two mice shown at the bottom did not undergo the extinction phase, and no histology was performed in these mice.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0033612.g003