Proof of Concept of Microbiome-Metabolome Analysis and Delayed Gluten Exposure on Celiac Disease Autoimmunity in Genetically At-Risk Infants
A. Samples are colored by time points, red, 7 d and 30 d, green, 6 m and 8 m, light blue, 10 m and 12 m, dark blue, 18 m and 24 m. B. Samples are colored by intervention groups. Group A: red, Group B: green. Blue: 7 d and 30 d time points prior to diet intervention. A and B: Gold, adult controls: subject 34 gluten-free diet for over 24 weeks and HLA DQ2/8+; subject 67 HLA DQ2/8−; subject 103 HLA DQ2/8+; subject 86; diagnosed with CD and HLA DQ2/8+.