Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface
Figure 6
Distributions of the predicted ranking of the CDR amino acids in the antibody-VEGF complex interfaces.
The x-axis shows the predicted ranking of the CDR amino acids in the five antibody-VEGF complex interfaces as shown in Figure 5. Detailed prediction results are shown in Table S9. The y-axis shows the percentage of the CDR amino acids predicted with the ranking shown in x-axis. The red line shows the distribution for the amino acids in the core interface, while the blue line shows the distribution for the amino acids in the rim interface. These two distributions are compared with random distribution shown as the flat dash line in the figure.