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Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection

Figure 3

Images of tissue inflammation and B. burgdorferi antigen in tissues from animals treated in the late, disseminated phase (Experiment 1).

For antigen detection, samples of tissue were stained for fluorescent detection (IFA) with anti-B. burgdorferi monoclonal (see Materials and Methods) antibody. (A) Hematoxylin &Eosin stain showing monocytic and lymphocytic infiltrate in a heart section (20×) of a treated animal (AM38). (B) Image of positive IFA staining from the heart tissue of the same animal.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0029914.g003