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Combinations of Histone Modifications Mark Exon Inclusion Levels

Figure 2

Pair-wise co-occurrence of histone modifications in the model.

(A) Rules predicting ‘spliced out’. Any each histone modification that occurs in any rule is labelled on the outer ring, and co-occurrence with other histone modifications are illustrated by ribbons across the circle. The width of the ribbon correlates to the number of rules where the two modifications co-occur as attributes. Colouring of the ribbons indicates ranking of number of rules with the given pair over the whole model with the lower 75% coloured in grey. The colours of the inner ring correspond to the colour in the outer ring in the other end of a given ribbon. The figure labels are ‘I’: H2BK5me1, ‘II’: H3K36me3, ‘III’: H3K4me1, ‘IV’: H3K9me1, ‘V’: H3K9me2, ‘VI’: H3K9me3, ‘VII’: H3R2me1, ‘VIII’: H4K16ac, ‘IX’: H4K20me1, ‘X’: H4K91ac; S: succeeding the exon, P: preceding the exon, E: on the exon; 0: is absent, 1: is present (e.g. “A P0” is interpreted as “H2BK5me1 preceding the exon is absent”). (B) Same as (A) but for the rules predicting ‘included’ exons. Images was generated using Circos [29].

Figure 2

doi: https://doi.org/10.1371/journal.pone.0029911.g002