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Clinical, Epidemiologic, Histopathologic and Molecular Features of an Unexplained Dermopathy

Figure 5

Representative histopathologic features of case-patient skin lesions.

A. Epidermal hyperplasia with compact orthokeratosis and hypergranulosis and perivascular inflammatory infiltrates in the dermis consistent with lichen simplex chronicus. B. Focal erosion with superficial ulceration and scale-crust consistent with excoriation. C. Mixed perivascular inflammatory cell infiltrates comprised of lymphocytes, neutrophils and eosinophils, suggestive of arthropod bite or drug reaction. D. Suppurative folliculitis comprised of eosinophils and neutrophils. Hematoxylin and eosin stain, original magnifications ×25 (A, B), ×100 (C), and ×50 (D).

Figure 5