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A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance

Figure 7

RKIP level modulations alters HT29 but not HCT116 CRC cells' sensitivity to chemotherapeutic agents.

A, HT29 and B, HCT116 cells were stably transfected with different retroviral expression vectors as indicated. Transfected cells were treated with doxorubicin for 48 h before harvesting. Extracts were prepared for western immunoblot analysis with the specific indicated antibodies. C, HCTT116 cells were stably transfected with different retroviral expression vectors as indicated. Transfected cells were treated with 5-FU for 48 h. Extracts were prepared for cytometric analysis to examine binding to 7-ADD and annexin V.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0029532.g007