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A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance

Figure 4

RKIP silencing induces nuclear translocation of NRF2.

A, Shows western blotting and densitometric measurements (upper panel) for NRF2, RKIP and β-actin loading control from total protein extracts of depicted cells. B, Shows western blots on nuclear fractions of HEK-control and HEK-499 cells in duplicates with Aurora B as loading control. C, Immunofluorescent confocal microscopy for NRF2 in the depicted cells showing increased nuclear localization of NRF2 in RKIP depleted HEK-499 cells. Western experiments were performed in duplicates and repeated twice.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0029532.g004