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Connecting the Dots between PubMed Abstracts

Figure 1

Constructing stories out of clique chains between PubMed IDs 19166837 (a document about IL-6) and 3000421 (a document about Poly ADP-ribose).

Figure (a) shows a path with the least stringent requirements. As the requirements become more and more stringent in (b) and (c), the story becomes longer. Figure (d) shows a significant story from both statistical and biological viewpoints. It connects one of the inflammatory cytokines IL-6 with brain injury and Poly(ADP-ribose) Polymerase (PARP) deficiency or inhibition. The generated hypothesis suggests that PAR/PARP could impact signaling of IL-6 or other interleukins. This story is covered in detail in Table 4. Fig. 9 depicts the dispersion plots of the four stories derived from the clique chains of this figure.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0029509.g001