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Antibodies Recognizing Mycobacterium avium paratuberculosis Epitopes Cross-React with the Beta-Cell Antigen ZnT8 in Sardinian Type 1 Diabetic Patients

Figure 8

Ab reactivities against MAP3865c epitopes are inhibited by the homologous ZnT8 epitopes.

(A) Ab+ and Ab-negative sera from T1D patients were pre-incubated overnight with saturating concentrations of MAP3865c125–133 (white bars), ZnT8178–186 (hatched bars), control (grey bars) or no peptide (black bars) and their reactivity on MAP3865c125–133-coated ELISA plates subsequently tested. (B) The same sera were preincubated with MAP3865c133–141 (white bars), ZnT8186–194 (hatched bars), control (grey bars) or no peptide (black bars) and their reactivity on MAP3865c133–141-coated ELISA plates subsequently tested. Bars depict means ± SEM of triplicate wells and results are representative of two separate experiments.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0026931.g008