A Novel Evolution-Based Method for Detecting Gene-Gene Interactions
Figure 5
Power of four statistics under three different model when the disease allele frequencies at the two loci are low.
The disease prevalence is assumed to be 1%. The disease allele frequencies at the two loci are 0.2 and 0.4, respectively. The power, at significance level α of 0.05, is obtained based on simulations of 500 cases and 500 controls. The green, red, blue, and cyan lines are the power of Fst based statistic, Pearson's Chi-square statistic, MI based statistic, and LD based statistic, respectively. Three plots (A, B, C) correspond to the dominant model, the additive model and the recessive model, respectively.