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The Role of PKR/eIF2α Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer

Figure 1

PKR mRNA levels are correlated with PKR protein levels in primary NSCLC tissues.

A. Western blot analysis of PKR and p-PKR protein in tumor samples. A densitometric analysis of the ratio of PKR or PKR to β-actin is represents normalized protein levels. Each lane represents a tumor sample from an individual patient. B. mRNA levels of corresponding samples were determined using quantitative real-time PCR. Levels of β-actin protein and its mRNA of the same sample were used as controls. C. Scatter plot of PKR protein expression correlated with mRNA expression (Spearman's rho = 0.55, p<0.001).

Figure 1

doi: https://doi.org/10.1371/journal.pone.0024855.g001