The Role of PKR/eIF2α Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer
A. Western blot analysis of PKR and p-PKR protein in tumor samples. A densitometric analysis of the ratio of PKR or PKR to β-actin is represents normalized protein levels. Each lane represents a tumor sample from an individual patient. B. mRNA levels of corresponding samples were determined using quantitative real-time PCR. Levels of β-actin protein and its mRNA of the same sample were used as controls. C. Scatter plot of PKR protein expression correlated with mRNA expression (Spearman's rho = 0.55, p<0.001).