Identification of the Pangenome and Its Components in 14 Distinct Aggregatibacter actinomycetemcomitans Strains by Comparative Genomic Analysis
Analysis of the size of the core genome (A) and whether the pangenome is open or closed (B and C). The number of common genes (A), new genes (B) and size of pangenome (C) are plotted as a function of the number of n of strains sequentially added. Circles show all different strain combinations for each n. Squares are the averages for each n. The continuous curve in A and B represents the least-squares fit of an exponential decay function. The extrapolated A. actinomycetemcomitans core genome size and average number of new genes are shown as dashed lines in top and middle plots respectively. Based on the curve, the core genome size is estimated to be about 2,060 genes. For every additional strain up to 16 new genes can be added to the open pangenome.