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Hippocampal-Dependent Spatial Memory in the Water Maze is Preserved in an Experimental Model of Temporal Lobe Epilepsy in Rats

Figure 4

Results obtained on the elevated plus maze.

(A) Time spent in the open arms for lithium-pilocarpine- (LIP) and kainate- (KA) treated rats of the Wistar strain. (B) Time spent in the open arms for lithium-pilocarpine- (LIP) and kainate- (KA) treated rats of the Sprague-Dawley strain. (C) Total distance travelled in the maze for the Wistar groups. (D) Total distance travelled in the maze for the Sprague-Dawley groups. Statistical differences are reported at different significance level for comparisons against the control group: ** p<0.01 and *** p<0.001. The number of animals per group is: Control-W n = 23; Control-SD n = 9; KA-W n = 12; KA-SD n = 16; LIP-W n = 10; LIP-SD n = 11.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0022372.g004