Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse
Figure 3
Mouse adaptive mutations on PB2 three dimensional maps.
Mutation sites are shown on ribbon structures of PB2 protein with space filling models of amino acids numbered in black for mutations found once, or red for positively selected mutations. (A) PB2 cap binding domain bound to m7GTP (in stick image); (B) PB2 C-terminal domain with the 627 site shown in stick image. (C) PB2 NLS with R753 (stick image) that forms a salt bridge with D701, NLS in red; (D) PB2 NLS in complex with human importin α5; NLS in red.