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Gain, Loss and Divergence in Primate Zinc-Finger Genes: A Rich Resource for Evolution of Gene Regulatory Differences between Species

Figure 2

An example of a gene cluster with species-specific loci.

Human (cluster chr7q11.21b, region, human chromosome 7∶63000000–63750000) was chosen as the reference for this Gbrowse display. Loci are depicted by rectangles. Orthologous loci are connected by lines. Colors indicate the species comparison: Red for human-chimpanzee and blue for human-orangutan. The human-rhesus macaque comparison is not shown, but can be viewed on our synteny browser (http://znf.igb.illinois.edu/cgi-bin/gbrowse_syn/znf_synteny/). Continuous stretches of chromosomes are shown in a box; orthologs located on other chromosomes (e.g. random chromosomes) are shown in separate boxes. Note the paralogs LLNL1099P and LLNL1181, an example for a human specific duplication, and ZNF722, an example for a gene duplicated in orangutan. Further note that for orangutan the reverse is shown, indicating an inversion on the lineage to humans and chimpanzees; the orangutan gene order is likely to be ancestral because it is shared by rhesus macaque (not shown).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0021553.g002