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A Flexible Approach for Highly Multiplexed Candidate Gene Targeted Resequencing

Figure 3

Comparison of targeted resequencing of independent samples.

We show an example of a 1,049 base captured region, occurring between coordinates 11096583 and 11097631 of chromosome 1. The fold-coverage from the three samples has been normalized by taking the ratio of fold-coverage at each position to the median depth for the sample, and then taking the log10 of that ratio. Purple lines indicate a capture oligonucleotide's target. The exons are indicated by the blue lines. Vertical lines, extending from the beginning and end of each captured amplicon, show that the discontinuities in depth are associated with the ends of captured targets.

Figure 3