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Proline-Rich Tyrosine Kinase 2 (Pyk2) Promotes Cell Motility of Hepatocellular Carcinoma through Induction of Epithelial to Mesenchymal Transition

Figure 3

Effects of Pyk2 on the phosphorylation and activation of Hic-5.

(A) Pyk2 over-expression promoted the membrane localization of Hic-5. Positive staining of Hic-5 (green, white arrow) was up-regulated in Pyk2 transfected Hep3B cells. (B) Effect of Pyk2 over-expression on the phosphorylation of Hic-5 in Hep3B cells. (C) Suppression of Pyk2 by PRNK down-regulated the localization of Hic-5 (green, white arrow) on cell membrane and (D) level of activated Hic-5 in MHCC97L cells.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0018878.g003