Proline-Rich Tyrosine Kinase 2 (Pyk2) Promotes Cell Motility of Hepatocellular Carcinoma through Induction of Epithelial to Mesenchymal Transition
(A) Pyk2 over-expression promoted the membrane localization of Hic-5. Positive staining of Hic-5 (green, white arrow) was up-regulated in Pyk2 transfected Hep3B cells. (B) Effect of Pyk2 over-expression on the phosphorylation of Hic-5 in Hep3B cells. (C) Suppression of Pyk2 by PRNK down-regulated the localization of Hic-5 (green, white arrow) on cell membrane and (D) level of activated Hic-5 in MHCC97L cells.