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Proline-Rich Tyrosine Kinase 2 (Pyk2) Promotes Cell Motility of Hepatocellular Carcinoma through Induction of Epithelial to Mesenchymal Transition

Figure 1

Pyk2 promoted cell motility of HCC cells.

(A) Overexpression of Pyk2 in Hep3B cells enhanced the formation of membrane ruffles while (B) suppression of Pyk2 in MHCC97L cells reduced the formation of membrane ruffles under the stimulation of PDGF and LPA. White arrows indicate the presence of membrane ruffles. (C) Effects of Pyk2 on cell migration of Hep3B and MHCC97L cells in presence of LPA. *, P<0.05. (D) The effect of over-expression of Pyk2 on the activation of Rac1 and RhoA in Hep3B cells by Rac1 and RhoA pull-down assays. Total Rac1 and RhoA were used as loading controls.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0018878.g001