In Vivo Dioxin Favors Interleukin-22 Production by Human CD4+ T Cells in an Aryl Hydrocarbon Receptor (AhR)-Dependent Manner
Figure 1
In vivo TCDD-exposure increases IL-22 but does not concomitantly affect IL-17A, IFN-γ and IL-10 production by PBMC.
Cytokine levels were assessed at d 7 in supernatants of PBMC activated by CD3-crosslinking (A) or by Staphylococcal Enterotoxin B (SEB) (B). IL-2 (20 U/ml) was added 48h after culture initiation. Individual data for a single TCDD-exposed individual (full symbols) and 9 (CD3-crosslinking) or 2 (SEB stimulation) different healthy individuals (empty symbols) are shown.