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Differential Consolidation and Pattern Reverberations within Episodic Cell Assemblies in the Mouse Hippocampus

Figure 9

Pattern reactivations are mainly driven by the invariant subpopulation.

(A) A typical trajectory during a drop event from 30 cm (gray/cyan/green/blue clusters indicate rest/sound/air 800 ms/drop 30 cm) is plotted using all of the responsive units. (B) Activation dynamics can be also observed in the MDA encoding subspace which uses only the modulated subpopulation of cells. (C) Activation dynamics can be further observed in the MDA encoding subspaces constructed from the invariant subpopulation only. (D) A typical reactivation trajectory is detected in whole population activity. (E) However, at this time point little reactivation is observed in the intensity-modulated subpopulation. (F) In contrast, the invariant responsive subpopulation exhibits a significant reactivation. Please note that the directionality of trajectory towards the drop cluster and away from the air-blow cluster or acoustic metal sound is confirmed in other rotated 3-D dimensions. (G) Comparison of distances from the resting state for all reactivation occurrences when using all of the responsive units reveals significant differences between basal states and reactivations. (H) No statistically significant reactivations in the intensity-modulated subpopulation. (I) Significant reactivations are observed in the intensity-invariant subpopulation (p<0.05).

Figure 9

doi: https://doi.org/10.1371/journal.pone.0016507.g009