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Differential Consolidation and Pattern Reverberations within Episodic Cell Assemblies in the Mouse Hippocampus

Figure 6

Hierarchical organization of CA1 cell assemblies from general-to-specific response-selectivity.

(A) Hierarchical clustering for simultaneously recorded 219 neurons (mouse #1) suggest a wide range of response selectivity to startling stimuli, ranging from general (top of the figure, responsive to all four type of startles), to sub-general (responses to a subset of two or three types of events), highly specific (1 type) and non-responsive units (bottom of the figure, in blue). The following formulas have been used during the hierarchical clustering procedures: the average responses to a startle Rstartle were first normalized to Rnormalized = (Rstartle – Rbasal activity)/(Raverage + Rbasal activity), where the average population activity during baseline activity is Raverage ≈2.7 To facilitate visualization of different classes, we retain only the units that have a positive change in their firing rates, and we display the quantities T = log(1+ Rnormalized) as a colormap. (B) Although exact percentages for these types of units may vary from animal to animal depending on the location of electrodes, pooled data from 7 animals (1623 neurons) indicate that this is a general property.

Figure 6