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Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine

Figure 10

Properties of type-7 interneurons.

(A) Spike rasters of silmultanously recorded pyramidal cells (in blue) and type-7 interneurons after ketamine injection, during running and slow-wave sleep are shown (left subpanels). The unit plotted for B and C is in red, and the second type-7 cell simultaneously recorded is in orange. The cross-correlation functions of the interneuron and pyramidal cell joint-activities are plotted on the right. The black line is the cross-correlation during the awake rest state. (B) The basic properties. The most upper left panel shows the average spike waveforms. Firing probability histograms suggest that the neuronal firing timing was not coupled to theta oscillations nor ripple oscillations (middle left and lower left panels). (C) ISI histograms and autocorrelograms in different states: after ketamine injection, during running, and during sleep respectively. Note the rhythmic peaks with 20 ms intervals in the sleep state and ketamine-induced anesthetic state.

Figure 10

doi: https://doi.org/10.1371/journal.pone.0015209.g010