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Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine

Figure 5

Properties of type-2 interneurons (putative bistratified cells).

(A) Spike rasters of silmultanously recorded pyramidal cells (blue) and bistratified cells (an example unit plotted here in red and remaining units in orange) after ketamine injection, during running and slow-wave sleep are shown (left panels). The cross-correlation functions of the interneuron and pyramidal cell joint-activities are plotted on the right. The black line in each plot is the cross-correlation during the awake rest state. (B) The basic properties of this example basket cell. The most upper left panel shows the average spike waveforms. The middle left panel illustrates the spike timing of this unit is negatively coupled with theta oscillations (p<0.001, Rayleigth's test). The lower left panel shows the significantly elevated firing rate throughout the entire ripple epochs. (C) Autocorrelograms in different states: after ketamine injection, during running, and during sleep respectively. Autocorrelograms are shown in two time scales: 0–200 ms and 0–1.5 sec.

Figure 5