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Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine

Figure 4

Properties of type-1 interneuron (putative basket cells).

(A) Spike rasters of silmultanously recorded pyramidal cells (blue) and basket cells (example plotted here in red, remaining units in orange) after ketamine injection, during running and slow-wave sleep are shown (left panels). The cross-correlation functions of the interneuron and pyramidal cell joint-activities are plotted on the right. The black line is the cross-correlation during the awake rest state. (B) The basic properties of this example basket cell. The most upper left panel shows the average spike waveforms of this unit. The middle left panel illustrates the strongly coupled spike timing of this unit with theta oscillations (p<0.001, Rayleigth's test). The lower left panel shows the significantly elevated firing rate during ripple epochs. (C) Autocorrelograms in different states: after ketamine injection, during running, and during sleep respectively. Autocorrelograms are shown in two time scales for better illustration: 0–200 ms and 0–1.5 sec.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0015209.g004