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Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine

Figure 2

Hippocampal ensemble firing pattern changes after ketamine injection.

(A–E) The spike raster plots show the activities of simultaneously recorded hippocampal neurons when the animal was asleep (A), awake resting (B), running (C), anesthetic state after ketamine injection (D), and recovery from ketamine (E). Each short vertical bar indicates a single spike, and each line indicates a single unit recorded. Pyramidal cells are shown in blue, and interneurons are shown in red. After ketamine injection, the population firing pattern has changed dramatically. Note the vertical alignments of spikes indicating the synchronous firing of pyramidal cells (D).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0015209.g002