The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in Tanzania
Figure 3
The relation between transmission reducing activity and Pfs230 and Pfs48/45 antibody concentration.
Transmission reducing activity is plotted as a continuous variable, the reduction in oocyst density in mosquitoes, on the Y axis against antibody concentration (optical density, OD) on the X-axis. Filled diamonds represent Pfs230 antibody responses; open circles Pfs48/45 antibody responses. The solid line represents the best fit for the association between Pfs230 antibody concentration and % oocyst reduction; % oocyst reduction = 100/1+10((0.697-OD Pfs230)*1.44); R2 = 0.56. The dashed line the association between Pfs48/45 antibody concentration and % oocyst reduction: % oocyst reduction = 100/1+10((0.490-OD Pfs48/45)*1.84); R2 = 0.45.