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Comprehensive Approach to Analyzing Rare Genetic Variants

Figure 3

Further results comparing power across rare variant approaches.

Results in Figures A and B show the effect of having both deleterious and protective rare variants. Figures C and D switches to a continuous trait, with Figure D showing the effect of having both deleterious and protective rare variants. Results are sorted by the plot that has the highest area, i.e., the most powerful overall. See the Figure 2 legend for additional details about the different simulations.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0013584.g003