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A Multi-Parameter, High-Content, High-Throughput Screening Platform to Identify Natural Compounds that Modulate Insulin and Pdx1 Expression

Figure 1

Fluorescent protein expression in living beta-cells infected with dual reporter lentivirus.

(A,B) A representative group of MIN6 cells is imaged in the EGFP or RFP channels. (C) Merged image shows the heterogeneity in insulin and pdx1 promoter activity between single cells. Hoechst was used to counterstain the nuclei. (D) Differential interference contrast microscopy image of the MIN6 cells from panels A–C.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0012958.g001