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From Knockouts to Networks: Establishing Direct Cause-Effect Relationships through Graph Analysis

Figure 3

Distribution of the mean absolute deviation for three knockout datasets.

Each point is the mean absolute deviation of the expression of a gene with respect to its wild type , calculated as , obviously excluding the knockout of gene from the averaged values. Our in silico knockout data (right) qualitatively resembles the distribution of the five DREAM4 InSilico_Size100 knockout datasets (middle), in contrast to those from the five DREAM3 InSilicoSize100 knockout datasets (left).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0012912.g003