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Herpes Simplex Virus 2 ICP0 Mutant Viruses Are Avirulent and Immunogenic: Implications for a Genital Herpes Vaccine

Figure 8

HSV-2 0ΔNLS replicates at the site of inoculation, but fails to spread.

(A) Sites of GFP expression (arrows), as visualized on Day 2 p.i., in the eyes of ICR mice inoculated with 100,000 pfu/eye of HSV-2 MS-GFP or HSV-2 0ΔNLS. (B) Progression of the spread of GFP expression across the faces of mice inoculated with HSV-2 MS-GFP or HSV-2 0ΔNLS as visualized on Days 2, 4, and 6 p.i. These experiments were performed on n = 3 mice per group, and the progression of infection is shown in a single representative mouse per group.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0012251.g008