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Herpes Simplex Virus 2 ICP0 Mutant Viruses Are Avirulent and Immunogenic: Implications for a Genital Herpes Vaccine

Figure 7

HSV-2 ICP0 mutant viruses are repressed by a Stat 1-dependent host response.

(A–C) Viral shedding on Day 2 p.i. from the eyes of (A) wild-type strain 129 mice, (B) lymphocyte-deficient rag2−/− mice, or (C) IFN-signaling-deficient stat1−/− mice inoculated bilaterally with 100,000 pfu/eye of wild-type HSV-2 MS, HSV-2 0ΔNLS, or HSV-2 0ΔRING (n = 10 mice per group). A single asterisk (*) denotes p<0.05 and a double asterisk (**) denotes p<0.001 regarding the probability, p, that viral shedding was equivalent to HSV-2 MS shedding in the same strain of mice. (D–F) Duration of survival of (D) strain 129 mice, (E) rag2−/− mice, or (F) stat1−/− mice following inoculation with wild-type HSV-2 MS, HSV-2 0ΔNLS, or HSV-2 0ΔRING (n = 10 mice per group). A double asterisk (**) denotes p<0.001 regarding the probability, p, that the duration of survival was equivalent to HSV-2 MS-infected mice of the same mouse strain.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0012251.g007